Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

• Hiroki Oguri,
• Haruki Mizoguchi,
• Hideaki Oikawa,
• Aki Ishiyama,
• Masato Iwatsuki,
• Kazuhiko Otoguro and
• Satoshi Ōmura

Beilstein J. Org. Chem. 2012, 8, 930–940, doi:10.3762/bjoc.8.105

• undertaken. Keywords: chemical diversity; divergent cyclization; indole alkaloids; modular assembly; rhodium-catalyzed cyclization–cycloaddition; skeletal and stereochemical diversity; Introduction Biologically intriguing natural products often possess cyclic scaffolds bearing dense arrays of functional

Recent developments in chemical diversity

• John A. Porco Jr

Beilstein J. Org. Chem. 2012, 8, 827–828, doi:10.3762/bjoc.8.92

• the advances in technology that enable progress in these areas. In the original paradigm for DOS, compound and library design were substantially based on the incorporation of functional, skeletal, and stereochemical diversity elements. An emerging theme in the area, as evident from many of the